Maintaining healthy arteries promotes blood circulation, tissue and organ oxygenation and longer life
VASCULAR VX™ is a next generation vascular support formula, helping to maintain arterial elasticity, and limiting potential for the pathological build-up in the arteries, which is responsible for atherosclerosis.
VASCULAR VX (ARONIA BERRY | SAFFRON | ARTICHOKE | APIGENIN)
REFERENCES:
(1) Zhao Y, et al. Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota. Sci Rep. 2021 Oct 18
(2) Daskalova E, et al. Black Chokeberry ( Aronia melanocarpa) Functional Beverages Increase HDL-Cholesterol Levels in Aging Rats. Foods. 2021 Jul
(3) Kasprzak-Drozd K, et al. The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases. Int J Mol Sci. 2021 Jun.
(4) Kadoglou N, et al. The cardiovascular-protective properties of saffron and its potential pharmaceutical applications: A critical appraisal of the literature. Phytother Res. 2021 Aug 26.
(5) Xing B, et al. Phytochemistry, pharmacology, and potential clinical applications of saffron: A review J Ethnopharmacol. 2021 Dec 5.
(6) Santos H, et al. The effect of artichoke on lipid profile: A review of possible mechanisms of action. Pharmacol Res. 2018 Nov
(7) Clayton Z, et al. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. AM J Physiol Heart Circ Physiol. 2021 Jul
(8) Gao H, et al. Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus. Cardiovasc Toxicol, 2021 Sept.
Yellow Longevity® is a high quality supplement which contains the most important natural yellows found in nature for health and anti-aging.
Key ingredients:
YELLOW LONGEVITY (Curcugen® | Berberine | Saffron | Apigenin)
REFERENCES:
(1) Dolcas-Biotech Research. 2021
(2) Sanjib K, et al. The enhanced bioavailability of free curcumin and bioactive-metabolite tetrahydrocurcumin from a dispersible, oleoresin-based turmeric formulation. Medicine (Baltimore). 2021 Jul.
(3) Zhang B, et al. Novel PGC-1 α/ATF5 Axis Partly Activates UPR mt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy. Oxid Med Cell Longev. 2020 Dec
(4) Shen L, et al. Curcumin and Aging.Biofactors. Jan-Feb 2013
(5) Samadi P, et al. Berberine: A novel therapeutic strategy for cancer. IUBMB Life. 2020 Oct.
(6) Ashrafizadeh M, et al. Berberine Administration in Treatment of Colitis: A Review. Curr Drug Targets. 2020.
(7) Li, S. et el. Protective Mechanism of Berberine on Human Retinal Pigment Epithelial Cells against Apoptosis Induced by Hydrogen Peroxide via the Stimulation of Autophagy. Oxid Med Cell Longev. 2021 Aug.
(8) Zheng Y, et al Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages. Aging (Albany NY) 2021 Feb
(9) Roshanravan N, et al. The therapeutic potential of Crocus sativus Linn.: A comprehensive narrative review of clinical trials. Phytother Res. 2021 Sep
(10) Lin C, et al. IGF-II-induced hypertrophy in H9c2 cardiomyocytes is ameliorated by saffron by regulation of calcineurin/NFAT abd CaMKII signaling. Environ Toxicol. 2021 Sep.
(11) Kashyap P, et al. Functionality of apigenin as a potent antioxidant with emphasis on bioavailability, metabolism, action mechanism and in vitro and in vivo studies: A review. J Food Biochem. 2021 Sep
(12) Clayton Z, et al. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 Jul.
For years, it has been known that resveratrol is one of the most effective anti-aging compounds studied. Beneficial effects on lifespan have been demonstrated across many research organisms, including worms and flies. In 2003, resveratrol was identified as a molecule which could activate SIRT1, mimicking the life extending benefits shown by calorie restriction. Furthermore, resveratrol also activates the anti-aging Nrf2 pathway, and AMPK which enhances NAD+ availability. (1) Cellular NAD+ levels are linked to longevity.
In a new study, the silkworm was used to further illustrate the life extending effects of resveratrol via significant improvement of antioxidant activity.. Oxidation is a key factor is anti-aging and shortening of the lifespan.(2)
Resveratrol was shown to activate antioxidant function in the silkworm via increased activity of the GST enzyme, key in the antioxidant enzyme system.
RESVERATROL ACTIVATES the GST Antioxidant System via
This research further validates the beneficial life extending benefits of resveratrol.
PURPLE LONGEVITY (Resveratrol : Pterostilbene)
REFERENCES:
(1) Li Z, et al. Aging and age‐related diseases: from mechanisms to therapeutic strategies. Biogerontology. 2021 Jan
(2) Song J, et al. Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori. J Pharm Anal. 2021 Jun
Boosting longevity is a function of many different attributes. Key among these are activating longevity genes (SIRT1 and FOXO) and decreasing levels of oxidative stress.
ACTIVATING LONGEVITY GENES -
BILBERRY ANTHOCYANINS (Blue Color)
GRAPE SEED EXTRACT (GSE) (5-8)
N-ACETYLCYSTEINE (GLUTATHIONE BOOSTER) (9-11)
=> (RESVERATROL | PTEROSTILBENE | LINGONBERRY)
REFERENCES:
(1) Li Y, et al. Effect of resveratrol and pterostilbene on aging and longevity. Biofactors. 2018 Jan.
(2) Scerbak C, et al. Lowbush cranberry acts through DAF-16/FOXO signaling to promote increased lifespan and axon branching in aging posterior touch receptor neurons. Geroscience. 2018 Apr.
(3) Ryyti R, et al. Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity. PLoS One. 2020 May.
(4) Li J, et al. Reduction of Aging-Induced Oxidative Stress and Activation of Autophagy by Bilberry Anthocyanin Supplementation via the AMPK-mTOR Signaling Pathway in Aged Female Rats. J Agric Food Chem. 2019 Jul.
(5) Mas-Capdevila A, et al. Changes in arterial blood pressure caused by long-term administration of grape seed proanthocyanidins in rats with established hypertension. Food Funct. 2020 Oct.
(6) Ruan Y, et al. Grape Seed Proanthocyanidin Extract Ameliorates Cardiac Remodelling After Myocardial Infarction Through PI3K/AKT Pathway in Mice. Front Pharmacol. 2020 Dec.
(7) Kadri S, et al. Protective effect of grape seed extract and orlistat co-treatment against stroke: Effect on oxidative stress and energy failure. Biomed Pharmacother. 2021 Apr.
(8) Kijima K, et al. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006 Jun.
(9) Niraula P, et al. N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression. Biogerontology. 2019 Aug.
(10) McCarty M, et al. Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function. Adv Nutr. 2021 Mar.
(11) DiNicolantonio J, et al. Supplemental N-acetylcysteine and other measures that boost intracellular glutathione can downregulate interleukin-1β signalling: a potential strategy for preventing cardiovascular events? Open Heart. 2017 Jul.
Lycium Barbarum (LB), also known as wolfberry, has been shown to provide powerful anti-aging effects. Significantly, long term feeding of LB in lab animals have shown increased longevity, eye (retina) support, including age-related macular degeneration (AMD), support liver health and boost of intestinal health and immunity.(1)
INCREASING MEAN LIFESPAN
PRESERVING RETINA FUNCTION
PROMOTES INTESTINE HEALTH / IMMUNE RESPONSE
PROTECTS LIVER
VISION VITALITY (Lycium Bararum)
REFERENCES:
(1) Ding Y, et al. Effects of long-term consumption of polysaccharides from the fruit of Lycium barbarum on host's health. Food Res Int. 2021 Jan.
(2) Tang R, et al. Lycium barbarum polysaccharides extend the mean lifespan of Drosophila melanogaster. Food Funct. 2019 Jul.
(3) Neelam K, et al. Fructus lycii: A Natural Dietary Supplement for Amelioration of Retinal Diseases. Nutrients. 2021 Jan.
(4) Ding Y, et al. Modulating effects of polysaccharides from the fruits of Lycium barbarum on the immune response and gut microbiota in cyclophosphamide-treated mice.
(5) Ding Y, et al. Modulating effects of polysaccharides from the fruits of Lycium barbarum on the immune response and gut microbiota in cyclophosphamide-treated mice. Food Funct. 2019 Jun.
(6) Liu R, et al. Protective effect of Lycium barbarum polysaccharide on di-(2-ethylhexyl) phthalate-induced toxicity in rat liver. Environ Sci Pollut Res Intl. 2021. Jan.
(7) Wang H, et al. Hepatoprotective effect of crude polysaccharide isolated from Lycium barbarum L. against alcohol-induced oxidative damage involves Nrf2 signaling. Food Sci Nutr. 2020 Oct..
PROTEOSTASIS. Defines the ability of the body to maintain the fidelity of biogenesis of protein (non-defective proteins), folding. movement, and removal of old protein aggregates. Especially significant is the removal of old damaged protein aggregates, which are detrimental to the functioning of the cell. Clearing old cellular debris, through a process called autophagy, greatly enhances the youthful functioning of the cell.
CURCUMIN ENHANCES AUTOPHAGY. Lifespan and autophagy are strongly
associated with one another. Calorie restriction, resveratrol and curcumin are known to improve autophagy and increase lifespan. In fact, all life extension mechanisms depend upon the importance of autophagy for clearing cellular damage.(1,2)
Aging affects molecular pathways that influence health and longevity. As a result, there is a reduction of cellular debris clearance (autophagy), decreased the pool of stem cells, increase in inflammation and cellular senescence.
CURCUMIN has been shown to by positively regulate longevity by through important molecular pathways, including IIS, mTOR and FOXO. Curcumin is a powerful activator of the body's antioxidant defense system, as an Nrf2 activator. As an antioxidant, curcumin stabilizes and protects telomeres. Inflammation is also a powerful promoter of aging. Curcumin inhibits the powerful inflammation transcription factor NF-κB and is associated with reduced levels of inflammation.(3) PROTEOSTASIS is impacted by all these aging pathways.(4) Therefore, curcumin supports longevity via aging signaling and proteostasis (autophagy).
Misfolded proteins in the brain are associated with poorly functioning autophagy. Autophagy removes aggregate protein accumulations which is responsible for neurodegeneration. Curcumin, research indicates, may help restore autophagy in the brain, to clear these misfolded proteins. (5) Oleuropein, a component of Olive Oil, in addition to curcumin, is implicated in mitophagy in the brain, removing old and dysfunction mitochondria. (6)
SIRT1 is an enzyme which regulates cellular processes relative to longevity. SIRT1 INCREASES PROTEOSTASIS ,which is an important component of the longevity effect. Natural activators of SIRT1 include Curcumin, Fisetin, Quercetin and Resveratrol.(15)
Cardiac remodeling through failure of autophagy, proteostasis and inflammation are believed to be a root cause of atrial fibrillation. Cardiomyocytes are replaced by non-functional proteins..(12. 13)
With age, cells become replicative scenescent - losing ability to produce new cells. Furthermore, scenescent cells are old cells. Old cells have been shown to lose proteostasis, which further limit the abilty of the cell to respond to external threats and maintain function. Curcumin and pterostilbene(11) helps inhibit cellular scenescence. Fisetin and quercetin are considered senolytics, which are capable of removing scenescent cells. (10) Importantly, recent research also indicates that curcumin also removes scenescent cells.(14)
CURCUMIN PXC® - Incorporates highly bioavailable curcumin Furthermore, Curcumin PXC also includes powerful supplemental ingredients in support of proteostasis.
CURCUMIN PXC® - THE PROTEOSTASIS CURCUMIN®
REFERENCES:
(1) Petrovski G, et al. Does autophagy take a front seat in lifespan extension? J Cell Mol Med. 2010 Nov;14(11):2543-51.
(2) Madeo F, et al. Can autophagy promote longevity? Nat Cell Biol. 2010 Sep;12(9):842-6.
(3) Zia A, et al. The role of curcumin in aging and senescence: Molecular mechanisms. Biomed Pharmacother, 2020 Dec.
The formation of insoluble fibers in the brain, including amyloid beta, Tau and α-synuclein are associated with dementia (especially correlated with aging). As such, targeted suppression and removal of these fibrils may be a strategic method of improving disease progression.
Results of studies demonstrated that Spearmint extract and Rosmarnic Acid (a component of Spearmint) can suppress the formation of amyloid fibrils. Furthermore, Rosmarinic Acid may breakdown already formed amyloid beta, Tau and α-synuclein fibrils.(1) Myricetin, another phenolic compound, also exhibits suppression of α-synuclein fibrils.(2)
In the brain, dementia Lewy Bodies involve primarily α-synuclein fibrils, while Alzheimer's Disease involve primarily amyloid beta fibrils.
HYPER LONGEVITY® (contains ROSMARINIC ACID / MYRICETIN)
CURCUMIN PXC® (contains ROSMARINIC ACID)
NEUROTREX® (contains ROSMARINIC ACID / MYRICETIN)
REFERENCES:
1. Ojawa K, et al. Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia. Nutrients. 2020 Nov 13.
2. Takahashi R, et al. Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity. J Neurochem. 2015 Sep.